Doublestranded RNA (dsRNA) is a viral product that induces innate immunity, leading to the production of interferon (IFN) alpha and beta, which can lead to the activation of hundreds of IFNstimulated genes that confer resistance to viruses dsRNA of more than 30bp length are reported to be is a key activator of the innate immune response against viral infections dsRNA is
Double stranded rna in humans-We identified Semliki Forest virus (SFV), a positivestrand RNA virus, as a potent activator of human but not murine NLRP1B SFV replication and the associated formation of doublestranded (ds) RNA was required to engage the NLRP1 inflammasome Moreover, delivery of long dsRNA was sufficient to trigger activationDNA and RNA are very similar After all, RNA is supposed to be a copy of DNA However, there are a few differences between the two molecules The biggest difference is in their shape DNA is a twostranded molecule in the form of a double helix RNA,
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Bosher and Labouesse 00) This type of posttranscriptional gene silencing (PTGS) was Prior to this work, researchers had assumed DNA viruses produced doublestranded RNA during infection, given that transcription occurs symmetrically on both top and bottom strands of viral DNA
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